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(max-width:352px){display:flex;flex-direction:column;}.button{@media screen and (max-width:352px){margin:0.2778rem auto;max-width:100%;width:90%;}}}}[data-page="efficacy"],[data-page="results"]{margin-top:2.2222rem;@media screen and (max-width:767px){main::after{margin-top:1.3889rem;}}div.definition{margin-top:1rem;}#mobile-curve{@media screen and (max-width:767px){margin-top:1.3889rem;}}.blue-box{h3{margin-bottom:0.5556rem;> span{clear:both;display:block;font-size:1rem;font-weight:bold;margin-bottom:0.5556rem;}}}.blue-box:not(:first-of-type){border-top-left-radius:0;border-top-right-radius:0;}@media screen and (min-width:768px){.blue-box:first-of-type::before{margin-top:-269px;}}.blue-box:last-of-type{border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;border-bottom:1.1111rem solid var(--navy);@media screen and (max-width:767px){border-bottom-left-radius:0.8333rem;border-bottom-right-radius:0.8333rem;border-bottom-width:0.5556rem !important;border-bottom:1.1111rem 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ul{margin-top:0.8333rem;margin-left:1.1111rem;@media screen and (max-width:767px){margin-left:1.9444rem;}li{margin-bottom:0.8333rem;}}}.region-hero h2{padding-left:5.5556rem;@media screen and (max-width:767px){padding-left:0;padding-top:1.1111rem;}}}#abnormality{border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;border-bottom:1.1111rem solid var(--navy);border-top-left-radius:0;border-top-right-radius:0;}#abnormalities{@media screen and (max-width:767px){border-bottom-width:0.5556rem;&::after{display:none;}}&::after{height:125%;}.blue-corner-box{background-color:var(--navy);bottom:0;height:0.7222rem;margin-bottom:-1.0556rem;margin-right:-1.1111rem;position:absolute;right:0;width:2.2222rem;@media screen and (max-width:768px){display:none;}}table thead tr{& > td:first-of-type{text-align:left;}& > th:first-of-type{padding-left:1.1111rem;text-align:left;}}.table tbody tr td:nth-of-type(2){text-align:center;}}#about-btc-callout-bottom{background-color:var(--navy);border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;border-left:1.1111rem solid var(--navy);border-right:1.1111rem solid var(--navy);border-top:0;color:var(--white);margin:0 auto;margin-top:-2.7778rem;max-width:66.6667rem;padding-bottom:2.2222rem;padding-left:5.1111rem;padding-right:5.1111rem;padding-top:2.7778rem;position:relative;&::before{content:"";background-color:var(--white);border-bottom-left-radius:1.1111rem;border-bottom-right-radius:1.1111rem;height:2.2222rem;left:0;position:absolute;top:0;width:100%;}&::after{content:"";background-color:var(--navy);bottom:0;height:110%;margin-bottom:0;position:absolute;right:0;top:unset;width:1.6667rem;}@media screen and (max-width:767px){border-bottom-color:var(--navy);border-bottom-left-radius:0.8333rem;border-bottom-right-radius:0.8333rem;padding-left:0;padding-right:0;padding-top:0;&::after,&::before{display:none;}}@media screen and (min-width:768px) and (max-width:1239px){max-width:90%;}.blue-corner-box{background-color:var(--navy);bottom:0;margin-right:-1.1111rem;position:absolute;right:0;width:2.2222rem;@media screen and (max-width:768px){display:none;}}.definition{padding-top:2.2222rem;@media screen and (max-width:767px){padding-top:1.6667rem;}}}#about-btc-ctas{padding-top:6.1111rem;@media screen and (max-width:767px){padding-bottom:2.5rem;padding-top:3.8889rem;&::after{margin-top:-2.7778rem !important;}&::before{content:"";background:var(--white);border-bottom-left-radius:6px;border-bottom-right-radius:6px;bottom:0;height:0.5556rem;left:0;margin-bottom:2.4444rem;margin-top:0;max-width:100%;position:absolute;top:unset;width:100%;z-index:999;}}@media screen and (min-width:768px) and (max-width:814px){&::after{height:105% !important;margin-top:-7.3889rem !important;}}& > .callout{border-top-left-radius:0 !important;border-top-right-radius:0 !important;margin-bottom:0.8333rem;margin-top:0.8333rem;}.view-content{display:flex;@media screen and (max-width:767px){flex-direction:column;align-items:center;}& > div{width:calc(100% / 3);@media screen and (max-width:767px){margin-bottom:3.3333rem;width:100%;}&:nth-of-type(2){margin-left:0.8889rem;margin-right:0.8889rem;}&:last-of-type{@media screen and (max-width:767px){margin-bottom:0;}}}& > div:first-of-type > div{border-top-left-radius:1.1111rem;@media screen and (max-width:767px){border-top-left-radius:0.8333rem;border-top-right-radius:0.8333rem;}}& > div:last-of-type > div{border-top-right-radius:1.1111rem;@media screen and (max-width:767px){border-radius:0;}}& > div > div{align-items:center;background-color:var(--navy);display:flex;flex-direction:column;height:100%;& > div{align-items:center;display:flex;flex-direction:column;}.views-field-field-info-box-header{color:var(--mint);font-family:"Nolan";font-size:1.3333rem;font-weight:bold;line-height:normal;margin-top:1rem;max-width:8.8889rem;text-align:center;}.views-field-field-info-box-copy{color:var(--white);line-height:normal;margin-top:1.3333rem;margin-bottom:0.7778rem;padding:0 1.25rem 1.1111rem 1.25rem;text-align:center;}.views-field-field-info-box-image{margin-top:-2.7778rem;max-width:6.3333rem;@media screen and (max-width:767px){max-width:4.6111rem;}}}}}#achievement{color:var(--body-color);&:first-of-type::after{height:115%;margin-bottom:-3.3333rem;}@media screen and (max-width:767px){border-bottom-left-radius:0;border-bottom-right-radius:0;&:first-of-type::after{height:300%;margin-top:-14.4444rem !important;}&:first-of-type::before{display:none;}}}#back-to-top{background-color:var(--dark-mint);border-bottom-left-radius:1.1111rem;border-top-left-radius:1.1111rem;bottom:0;color:var(--white);display:none;height:1.6667rem;justify-content:center;margin-bottom:13.8889rem;margin-right:-2.6667rem;position:fixed;right:0;width:4.4444rem;z-index:14;&.active{display:flex;}@media screen and (min-width:768px){margin-bottom:16.3889rem;margin-right:-2.7778rem;}&:hover{@media screen and (min-width:768px){margin-right:0;}}& > a{color:var(--white);text-decoration:none;p,&:active,&:visited{color:var(--white);}}p{font-size:0.8889rem;margin-right:-0.8889rem;padding:0.2778rem;&::before{content:"";border-left:2px solid var(--white);border-top:2px solid var(--white);left:0;padding:0.2778rem;position:absolute;top:0;transform:translate(12px,12px) rotate(45deg);}}}#achievement h3,#adverse-reactions h3,#abnormalities h3,#progression-free h3,#recommended-dosage h3,#responses-sustained h3{color:var(--dark-mint) !important;font-size:1.3333rem !important;font-weight:bold !important;margin-top:0.5556rem;@media screen and (max-width:767px){font-size:1.1111rem !important;}}#progression-free img,#overall-survival img{margin-bottom:1.1111rem;margin-top:1.1111rem;}#adverse-reactions{&::after{margin-right:-3.2778rem;margin-top:0.3333rem;top:0;}@media screen and (max-width:767px){&::after{bottom:0;height:120%;margin-right:0;top:unset;}&::before{display:none;}border-radius:0;border-top-left-radius:0.8333rem;}.callout{margin-bottom:1.1111rem;}.list{margin:1.1111rem 0;}.table{table{thead tr > th:first-of-type{padding-left:1.1111rem;text-align:left;}}tr:not(.title) td{text-align:center;&:first-of-type{text-align:left;}}.title{align-items:center;border-bottom:0;border-right:0;color:var(--mint);font-weight:bold;justify-content:flex-start;}}}#block-fluffiness-content{margin-top:2.7778rem;@media screen and (max-width:767px){margin-top:1.3889rem;}}.path-frontpage #hero{min-height:400px;padding:100px 0;background-image:url(/themes/custom/fluffiness/images/hero-banner.jpg);background-size:cover;.region-hero{&:before,&:after{content:none;}}@media screen and (max-width:767px){padding:0;background-image:url(/themes/custom/fluffiness/images/hero-banner-m.jpg);display:flex;justify-content:center;align-items:flex-end;}@media screen and (min-width:1800px){align-items:center;height:30vw;max-height:680px;.region-hero{height:100%;width:100%;display:flex;align-items:center;}}@media screen and (min-width:2500px){background-size:2500px;background-repeat:no-repeat;background-position:center;background-color:#fff;}}#block-fluffiness-herohomepage{display:flex;justify-content:flex-end;max-width:1240px;width:100%;padding:0;.text-formatted{max-width:500px;}@media screen and (max-width:767px){height:100%;}& > div{@media screen and (max-width:767px){padding:30px;}img{max-width:500px;width:100%;height:auto;margin:0 0 10px;}p{color:var(--white);font-family:"Nolan";font-size:18.5px;font-weight:bold;@media screen and (max-width:767px){font-size:12px;}}}.hero-top-curve,.hero-bottom-curve{display:none;}.hero-bottom-curve{background-image:url(/sites/default/images/homepage-hero-curve-bottom.png);margin-bottom:-2.3889rem;bottom:0;width:60%;background-position-x:1.1111rem;}.hero-top-curve{background-image:url(/sites/default/images/homepage-hero-curve-top.png);margin-top:0;top:0;}}.path-frontpage .nccn-cta{display:flex;padding:28px 40px;border-radius:10px;background:linear-gradient(1.81deg,#060d1f -30.79%,#0c2572 158.01%);color:#fff;gap:0 40px;max-width:890px;.heading{@media (min-width:768px){flex:0 0 270px;border-right:1px solid var(--mint);padding-right:40px;}}.content{@media (min-width:768px){align-self:center;}}@media (max-width:768px){flex-direction:column;.content p{font-size:16px;text-align:center;}}}#block-fluffiness-efficacyanchorlinks{background-color:var(--light-gray);bottom:0;box-shadow:var(--box-shadow-2);font-size:0.8889rem;left:0;margin-bottom:-2.0556rem;position:absolute;width:100%;transition:none;@media screen and (max-width:374px){margin-top:11rem;}@media screen and (min-width:375px) and (max-width:767px){margin-top:8.3333rem;}@media screen and (max-width:767px){bottom:unset;top:0;&.menu-open{ul li > a{display:block;}.dropdown{margin-top:0.7778rem;transform:rotate(45deg);}}}& > div{transition:none;}ul{display:flex;justify-content:space-between;margin:0 auto;max-width:16rem;width:100%;@media screen and (max-width:767px){align-items:center;flex-direction:column;width:100%;}}li > a{color:var(--navy);font-family:"Inter";letter-spacing:normal;line-height:2.25rem;@media screen and (max-width:767px){display:none;&.active{display:block;line-height:2.5rem;}}&.active,&:hover{font-weight:bold;}}.dropdown{display:none;@media screen and (max-width:767px){border-left:0.1667rem solid var(--navy);border-top:0.1667rem solid var(--navy);display:block;height:0.6667rem;margin-right:2.2222rem;margin-top:0.6667rem;position:absolute;right:0;transform:rotate(225deg);width:0.6667rem;}}}#block-fluffiness-importantsafetyinformation,#block-fluffiness-importantsafetyinformation--2{> div > div{align-items:flex-start;display:flex;flex-direction:column;margin-bottom:0;margin-top:0.8333rem;position:relative;& > div:first-of-type{display:flex;flex-direction:column;& > div:last-of-type{margin:1.1111rem 0;}}.boxed{border:0.1111rem solid var(--black);color:var(--body-color);font-weight:bold;margin-bottom:0.35rem;margin-top:0.35rem;padding:1rem;@media screen and (max-width:767px){margin-bottom:-0.4444rem;}p{margin-bottom:0;& > span{display:flex;justify-content:center;margin-bottom:-0.5556rem;text-align:center;text-transform:uppercase;}}}}h3{margin-bottom:1.1111rem;@media screen and (max-width:767px){margin-bottom:0.5556rem;}}h4{margin:-0.5556rem 0 0.5556rem;@media screen and (max-width:767px){font-size:1.1111rem;}}}#block-fluffiness-importantsafetyinformation{& > div > div .boxed > p{@media screen and (min-width:768px){margin-left:1.67rem;margin-right:1.5rem;}}.expand{display:none;}}#block-fluffiness-importantsafetyinformation--2{background-color:var(--white);bottom:0;box-shadow:var(--box-shadow-1);margin-bottom:-45.5556rem;position:fixed;width:100%;z-index:1;&.hidden{bottom:-999999px;}}#block-fluffiness-main-menu > ul{border-top:0.0556rem solid var(--mint);display:flex;justify-content:flex-end;margin:0;@media screen and (max-width:1023px){background:var(--white);border:0;display:none;flex-direction:column;left:0;margin-top:-0.5556rem;padding-top:1.1111rem;position:absolute;width:100%;}& > .menu-item{margin-left:1.3333rem;margin-right:1.3333rem;@media screen and (max-width:1023px){font-weight:bold;}&:first-of-type{display:none;}&:nth-of-type(2){@media screen and (min-width:1024px){margin-left:0;}}&:last-of-type{border:1px solid transparent;margin-right:0;padding-right:0.8333rem;position:relative;transition:none;@media screen and (min-width:1024px){margin-left:0;}&::before{content:"";border-right:0.1111rem solid var(--navy);border-top:0.1111rem solid var(--navy);margin-right:0.5556rem;margin-top:1.1111rem;padding:0.2778rem;position:absolute;right:0;top:0;transform:rotate(135deg);}&.active{border-bottom-left-radius:0;border-bottom-right-radius:0;border-bottom:0;border-radius:0.2778rem;margin-right:0;position:relative;@media screen and (min-width:1024px){border:0.0556rem solid var(--navy);}&::after{content:"";border-right:0.0556rem solid var(--navy);border-top:0.0556rem solid var(--navy);position:absolute;right:0;top:0;@media screen and (max-width:1023px){content:none;}}&::before{border-bottom:0.1111rem solid var(--dark-mint);border-left:0.1111rem solid var(--dark-mint);border-right:0;border-top:0;margin-top:1.5rem;@media screen and (max-width:1023px){margin-right:2.2222rem;margin-top:1rem;}}.dropdown{display:block;z-index:4;@media screen and (max-width:1023px){align-items:flex-start;border:0;display:flex;flex-direction:column;margin-left:0;margin-top:6.7222rem;width:100%;}.menu-item > a{font-weight:normal;}}}&:hover{@media screen and (min-width:1024px){border-bottom-left-radius:0;border-bottom-right-radius:0;border-bottom:0;border-radius:0.2778rem;margin-right:0;position:relative;@media screen and (min-width:1024px){border:0.0556rem solid var(--navy);}&::after{content:"";border-right:0.0556rem solid var(--navy);border-top:0.0556rem solid var(--navy);position:absolute;right:0;top:0;@media screen and (max-width:1023px){content:none;}}&::before{border-bottom:0.1111rem solid var(--dark-mint);border-left:0.1111rem solid var(--dark-mint);border-right:0;border-top:0;margin-top:1.5rem;@media screen and (max-width:1023px){margin-right:2.2222rem;margin-top:1rem;}}.dropdown{display:block;z-index:4;@media screen and (max-width:1023px){align-items:flex-start;border:0;display:flex;flex-direction:column;margin-left:0;margin-top:6.7222rem;width:100%;}.menu-item > a{font-weight:normal;}}}}&.inactive ul.dropdown{@media screen and (max-width:1024px){display:none !important;}}}align-items:center;display:flex;a{line-height:normal;max-width:7.2222rem;padding-bottom:0.8333rem;padding-top:0.5556rem;@media screen and (max-width:1023px){font-size:1rem;max-width:100%;}}}a.is-active,a:hover{color:var(--dark-mint);font-weight:bold;}.dropdown{background-color:var(--white);border-bottom:0.0556rem solid var(--navy);border-left:0.0556rem solid var(--navy);border-radius:0.2778rem;border-right:0.0556rem solid var(--navy);border-top-left-radius:0;border-top-right-radius:0;border-top:0;display:none;margin-left:-0.0556rem;margin-right:0;margin-top:9rem;padding:0.5556rem 1.5rem 0.5556rem;position:absolute;transition:none;width:8.1667rem;z-index:1;@media screen and (min-width:1024px) and (max-width:1189px){width:101%;}@media screen and (min-width:1190px){width:101.5%;}.menu-item:first-of-type{margin-bottom:0.7222rem;}}}#block-fluffiness-nextpagebutton{position:absolute;right:0;}#block-fluffiness-secondarynavigationlinks{max-width:45.8333rem;& > div p:first-of-type{font-size:0.7778rem;@media screen and (max-width:767px){margin-bottom:0.5556rem;margin-top:0.5556rem;}}}#block-fluffiness-site-branding{margin-left:1.389rem;margin-right:4.8333rem;margin-top:1.2222rem;transition:none;@media screen and (max-width:1023px){left:0;margin-left:-1.1111rem;margin-top:3.3333rem;margin:0;position:absolute;top:0;}@media screen and (min-width:768px) and (max-width:1205px){margin-left:-0.5556rem;margin-right:1.1111rem;margin-top:1.1111rem;}img{width:220px;transition:none;@media screen and (max-width:1023px){margin-left:1.1111rem;margin-top:4.4444rem;max-width:6.3333rem;}@media screen and (max-width:374px){margin-top:6.3889rem;}@media screen and (min-width:768px) and (max-width:1023px){margin-top:2.2222rem;margin-left:1.6667rem;}}}#definition-block{margin-top:1.6667rem;}#demographics{@media screen and (max-width:767px){border-bottom-width:0.5556rem !important;&::after{display:none !important;}}@media screen and (min-width:768px){&:last-of-type::after{height:105%;}}.blue-corner-box{background-color:var(--navy);bottom:0;height:0.7222rem;margin-bottom:-1.0556rem;margin-right:-1.1111rem;position:absolute;right:0;width:2.2222rem;@media screen and (max-width:768px){display:none;}}}#homepage-ctas{max-width:890px;display:flex;gap:30px;justify-content:space-between;margin-bottom:1.6667rem;margin-top:2.9444rem;@media screen and (max-width:767px){display:block;flex-direction:column;margin-top:0.2778rem;}.homepage-cta{display:flex;flex-wrap:wrap;&:first-child{flex-basis:450px;p{max-width:300px;padding-right:100px;&:last-child{margin-left:95px;}}img{max-width:65px;max-height:72px;margin-right:30px;@media screen and (max-width:767px){height:auto;}}}&:last-child{img{max-width:52px;max-height:72px;margin-right:30px;@media screen and (max-width:767px){height:auto;}}p{max-width:75%;&:last-child{margin-left:85px;}}}@media screen and (max-width:767px){margin-right:0;width:100%;}p{color:var(--navy);font-weight:bold;margin-bottom:1.1111rem;max-width:300px;}.button{color:var(--white);display:flex;font-weight:bold;justify-content:center;letter-spacing:normal;padding:1rem 1.3889rem;width:-moz-max-content;width:max-content;&:focus,&:hover,&:focus-visible{box-shadow:var(--box-shadow-1);outline:0;transform:scale(1.05);}}@media (max-width:768px){display:block;img{margin:40px 0;}p:nth-child(n),p:last-child{max-width:100%;margin-left:0 !important;margin-bottom:20px;padding:0;}}}}#binds{color:var(--body-color);@media screen and (max-width:767px){border-bottom-width:0.5556rem;padding-bottom:1.1111rem;}&:first-of-type::after{height:100%;}@media screen and (max-width:767px){&:first-of-type::after{height:140%;}}.callout{color:var(--white);}}#block-fluffiness-views-block-homepage-ctas-block-1{margin-top:2.9444rem;.views-field-field-homepage-cta-copy{color:var(--navy);margin-bottom:1.1111rem;}.views-field-field-homepage-cta-image-1 img{height:4.0556rem;margin-bottom:1.3889rem;width:auto;}.views-field-field-homepage-cta-link{align-items:center;background-color:var(--dark-mint);border-radius:2.2222rem;display:inline-block;a{color:var(--white);display:flex;font-weight:bold;justify-content:center;letter-spacing:-0.0278rem;padding:0.5556rem 0.7778rem;}}}#block-fluffiness-aboutbtcsummaryofinfoboxes{border-left:1.1111rem solid var(--navy);border-right:1.1111rem solid var(--navy);margin:0 auto;max-width:66.6667rem;padding-bottom:1.6667rem;padding-left:6vw;padding-right:6vw;padding-top:0.8333rem;position:relative;&::after{content:"";background-color:var(--white);border-radius:1.1111rem;height:2.2222rem;left:0;margin-bottom:-0.8333rem;position:absolute;bottom:0;width:100%;}}#characteristics.blue-box{border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;border-bottom:1.1111rem solid var(--navy);border-top-left-radius:0;border-top-right-radius:0;padding-bottom:2.2222rem;padding-top:2.2222rem;.callout{margin-bottom:1.6667rem;}}#content{position:relative;z-index:12;@media screen and (max-width:767px){margin:0 auto;padding-left:0.8333rem;padding-right:0.8333rem;width:100%;}h3{color:var(--navy);font-size:1.5556rem;font-weight:normal;text-transform:uppercase;}}#progression-free{@media screen and (max-width:767px){border-radius:0 !important;}.wrapper{& > div{background-color:var(--navy);border:0.5556rem solid var(--navy);border-radius:1.1111rem;overflow:hidden;width:25%;& > div{color:var(--white);padding:0.5556rem 0 0;border-radius:0.5556rem;overflow:hidden;&:first-of-type{border-bottom:0.5556rem solid var(--navy);}& > div p{background-color:var(--white);}& > p:first-of-type{color:var(--white);}}& > p{background-color:var(--coral);margin-top:-0.5556rem;padding-bottom:0.5556rem;padding-top:0.5556rem;text-align:center;}& > div{background-color:var(--white);border-bottom-left-radius:1.1111rem;border-bottom-right-radius:1.1111rem;padding-top:0;padding-bottom:0.2778rem;& > p{background-color:var(--coral);color:var(--white);}p{background-color:var(--coral);color:var(--navy);padding:0.5556rem 0;text-align:center;}}}}.callout{margin-bottom:1.6667rem;margin-top:0;}.definition{color:var(--body-color);}}#dose-modifications{border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;border-bottom:1.1111rem solid var(--navy);border-top-left-radius:0;border-top-right-radius:0;@media screen and (max-width:767px){border-bottom-width:0.5556rem;padding-bottom:1.6667rem;&::after{display:none;}}&::after{height:117%;}& > ul.list{margin-bottom:1.1111rem;}.blue-corner-box{background-color:var(--navy);bottom:0;height:0.7222rem;margin-bottom:-1.0556rem;margin-right:-1.1111rem;position:absolute;right:0;width:2.2222rem;@media screen and (max-width:768px){display:none;}}h3{margin-bottom:1.1111rem;}.list-wrapper{margin-bottom:0.8333rem;}.table{margin-top:1.1111rem;tbody tr{&:nth-of-type(2) td{border-right:0.0556rem solid var(--gray);}&:nth-of-type(3) .green-header-copy{position:relative;top:2.2222rem;}&:not(.title) td{@media screen and (max-width:389px){padding-left:0.2778rem;padding-right:0.2778rem;font-size:0.8889rem;}}td.vertical-align-top{@media screen and (max-width:767px){padding-top:1.1111rem;vertical-align:top;}}&.mobile .green-header-copy{@media screen and (max-width:767px){top:0;}}.green-header-copy{position:relative;top:6.3889rem;}}tr.mobile{@media screen and (max-width:767px){border-bottom:0 !important;border-top:0 !important;}}tr.mild td:first-of-type{padding-bottom:30.5556rem;.green-header-copy{position:relative;@media screen and (max-width:767px){top:0;}}}tr.pneu td:first-of-type{padding-bottom:3rem;.green-header-copy{position:relative;top:1.3889rem;@media screen and (max-width:767px){top:0;}}}tr.half td:first-of-type{padding-bottom:30.5556rem;.green-header-copy{position:relative;@media screen and (max-width:767px){top:0;}}}.green-bg{background-color:var(--mint);border-bottom:0.0556rem solid var(--navy);color:var(--navy);}td.bg-mint{border-top:0;}.bg-mint{vertical-align:top;}.border-left{border-left:0.0556rem solid var(--navy);}.list{padding-top:0.5556rem;ul.circle{li{&::before{content:"o";color:var(--dark-coral);font-size:0.6667rem;left:0;margin-top:0.2222rem;position:absolute;top:0;}}}}.list li{text-align:left;@media screen and (max-width:389px){font-size:0.8889rem;}}}}#fix-mobile-dropdown-arrow{left:11rem;margin-top:-0.5rem;padding:3.75rem 50%;position:absolute;top:0;z-index:999;@media screen and (min-width:1024px){display:none !important;}}#floating-isi{background-color:var(--white);box-shadow:var(--box-shadow-1);bottom:0;height:30%;left:0;overflow:hidden;position:fixed;width:100%;z-index:15;@media screen and (max-width:732px){height:25%;}@media screen and (min-width:733px) and (max-width:767px){height:21.5%;}#block-fluffiness-importantsafetyinformation .container h3{@media screen and (max-width:767px){padding-right:0.8333rem;}}h3{@media screen and (max-width:767px){display:none;}@media screen and (min-width:768px){display:block !important;}}.floating-isi-title{display:block;@media screen and (min-width:768px){display:none !important;}}.expand{display:block;height:1rem;margin:0;margin-right:-1.6667rem;position:absolute;right:0;top:0;width:1rem;@media screen and (max-width:767px){height:1.3333rem;margin-right:0.8333rem;margin-top:-0.0556rem;position:absolute;right:0;top:0;width:1.3333rem;}}.indication{margin-right:2%;width:48%;}.region-isi .container > div:first-of-type{flex-direction:row;@media screen and (max-width:767px){flex-direction:column-reverse;}& > div{width:50%;@media screen and (max-width:767px){width:100%;}}& > div:last-of-type{margin-top:0;}}}#isi{.indication > h3{display:block !important;}.floating-isi-title{display:none !important;}}#jazz-cares{border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;border-bottom:1.1111rem solid var(--navy);&::before{margin-right:-13.5556rem;margin-top:-14.7222rem;}@media screen and (max-width:767px){border-bottom-width:0.5556rem;&::after{border-right:0.5rem solid var(--navy) !important;margin-bottom:1.1111rem;margin-right:0;}}.blue-corner-box{background-color:var(--navy);bottom:0;height:1.0556rem;margin-bottom:-1.0833rem;margin-right:-0.8333rem;position:absolute;right:0;width:4.4444rem;@media screen and (max-width:767px){display:none;}}.callout{border-top-left-radius:0;border-top-right-radius:0;@media screen and (max-width:767px){border-top-left-radius:0 !important;border-top-right-radius:0 !important;margin-top:-0.2778rem;}}.message{align-items:center;display:flex;@media screen and (max-width:767px){flex-direction:column;}img{max-width:17.7778rem;@media screen and (max-width:767px){margin-bottom:-0.8333rem;margin-top:-1.9444rem;max-width:117%;}}}.wrapper{@media screen and (max-width:767px){margin-top:1.1111rem;}.callout{border-top-left-radius:0;border-top-right-radius:0;}.items{display:flex;margin-bottom:0.8333rem;@media screen and (max-width:767px){flex-direction:column;}}.item{background-color:var(--navy);color:var(--white);text-align:center;margin:0 0.2778rem;padding:1.1111rem;width:calc(100% / 3);@media screen and (max-width:767px){margin:0;padding:1.3889rem;width:100%;}&:first-of-type{border-top-left-radius:1.1111rem;margin-left:0;@media screen and (max-width:767px){border-top-left-radius:0.8333rem;border-top-right-radius:0.8333rem;}}&:nth-of-type(2){@media screen and (max-width:767px){margin-bottom:0.5556rem;margin-top:0.5556rem;}}&:last-of-type{border-top-right-radius:1.1111rem;margin-right:0;@media screen and (max-width:767px){border-top-right-radius:0;border-bottom-left-radius:0;border-bottom-right-radius:0;}}.title{align-items:center;color:var(--mint);display:flex;height:4.4444rem;justify-content:center;margin-bottom:0.8333rem;text-transform:uppercase;@media screen and (max-width:767px){justify-content:flex-start;}img{max-width:3.5rem;margin-right:0.8333rem;width:100%;@media screen and (max-width:767px){margin-right:1.6667rem;}}p{font-family:"Nolan";font-size:1.3333rem;font-weight:bold;text-align:left;}}}}}#leaving-modal{@media screen and (max-width:367px){margin-top:8.3333rem;max-height:35vh;}p.heading{font-family:"Nolan";font-size:1.5556rem;font-weight:bold;line-height:1.389rem;margin-bottom:1.6667rem;padding:0 1.6667rem;text-transform:uppercase;@media screen and (max-width:767px){font-size:1.3333rem;margin:0 auto;padding-left:0;padding-right:0;}&:after{content:none;}}.scroll-container{overflow:hidden;@media screen and (max-width:767px){margin-left:0;margin-right:0;}}.wrapper{display:flex;justify-content:space-evenly;margin:0 auto;padding-bottom:2.2222rem;max-width:100%;width:75%;z-index:1;@media screen and (max-width:767px){padding-top:0.8333rem;width:90%;}.button{color:var(--white);margin:0;min-width:6.6667rem;}}}#modal-container{background-color:rgb(3,64,93,0.75);display:none;position:fixed;width:100%;height:100%;top:0;left:0;z-index:9999;.close-modal{margin:1.6667rem 2.2222rem;position:absolute;right:0;top:0;z-index:3;}}#mechanisms{border-bottom:0;padding-top:1.1222rem;@media screen and (max-width:767px){padding-top:0;}.wrapper{align-items:stretch;display:flex;flex-direction:row;margin-bottom:1.6667rem;margin-top:1.6667rem;@media screen and (max-width:767px){flex-direction:column;margin-top:0;}> div{align-content:center;display:grid;padding-bottom:0.8333rem;padding-left:1.6667rem;padding-right:1.6667rem;padding-top:0.2778rem;position:relative;width:calc(100% / 3);@media screen and (max-width:767px){padding-left:0;padding-right:0;}> *{line-height:normal;text-align:center;}.arrow{display:flex;flex-direction:column;height:100%;justify-content:center;position:absolute;right:0;@media screen and (max-width:767px){bottom:0;flex-direction:row;height:auto;margin-bottom:1.2222rem;width:100%;}div{border-radius:0.0833rem;border-right:0.1667rem solid var(--navy);border-top:0.1667rem solid var(--navy);height:0.8333rem;padding:0;transform-origin:1.0556rem 2rem;transform:rotate(45deg);width:0.8333rem;@media screen and (max-width:767px){height:0.8333rem;margin-bottom:-1.111rem;transform-origin:unset;transform:rotate(135deg);width:0.8333rem;}&::before{content:"";border-top:0.1667rem solid var(--navy);position:absolute;right:0;top:0;transform-origin:0.7222rem 0.3194rem;transform:rotate(135deg);width:1.3889rem;}}}}> div:first-of-type{padding-left:0;width:45%;@media screen and (max-width:767px){padding-bottom:3.3333rem;width:100%;}> div:first-of-type{position:relative;@media screen and (max-width:767px){&::after{content:"";border-bottom-left-radius:0.2778rem;border-bottom-right-radius:0.2778rem;border-bottom:0.1667rem solid var(--navy);border-left:0.1667rem solid var(--navy);border-right:0.1667rem solid var(--navy);bottom:0;height:1.1111rem;left:0;margin-bottom:-1.6667rem;position:absolute;width:100%;}}}img{max-width:17.7778rem;width:105%;@media screen and (max-width:767px){margin-left:5%;margin:0 auto;margin-bottom:0.6667rem;max-width:100%;width:100%;}}p{color:var(--body-color);@media screen and (min-width:768px){margin-top:2.2222rem;}}}> div:nth-of-type(2){padding-left:2.5rem;padding-right:2.5rem;width:60%;@media screen and (max-width:767px){margin-top:0.1667rem;padding-left:0;padding-right:0;width:100%;.wrap::after{content:"";border-bottom-left-radius:0.2778rem;border-bottom-right-radius:0.2778rem;border-bottom:0.1667rem solid var(--navy);border-left:0.1667rem solid var(--navy);border-right:0.1667rem solid var(--navy);bottom:0;height:1.1111rem;left:0;margin-bottom:-0.5556rem;position:absolute;width:100%;}}.arrow{@media screen and (max-width:767px){margin-bottom:-1rem;}}.callout{margin:0.5556rem 0;}}> div:last-of-type{align-items:flex-end;display:flex;flex-direction:column;justify-content:space-evenly;padding-right:0;position:relative;@media screen and (max-width:767px){align-items:center;margin-top:3.0556rem;padding:0;width:100%;}img{margin-top:-2.2222rem;max-width:9.6667rem;@media screen and (max-width:767px){margin-top:-0.8333rem;max-width:8.6111rem;}}p:first-of-type{color:var(--dark-mint);}}> div:first-of-type::before,> div:nth-of-type(2)::before{content:"";border-bottom-right-radius:0.2778rem;border-bottom:0.1667rem solid var(--navy);border-right:0.1667rem solid var(--navy);border-top-right-radius:0.2778rem;border-top:0.1667rem solid var(--navy);height:100%;position:absolute;right:0;top:0;width:0.8333rem;}@media screen and (max-width:767px){> div:first-of-type::before,> div:nth-of-type(2)::before{display:none;}}}}#menu-trigger{border-bottom:2px solid var(--navy);border-top:2px solid var(--navy);display:inline-block;height:1.2222rem;margin-right:1.6667rem;margin-top:5.3333rem;position:absolute;right:0;top:0;width:1.2222rem;@media screen and (max-width:374px){margin-top:7.7778rem;}@media screen and (max-width:1023px){width:2rem;}@media screen and (min-width:1024px){display:none;}&.active{border:0;& > div:first-of-type{margin-top:0.4639rem;transform:rotate(45deg);}& > div:last-of-type{display:block;margin-top:-0.147rem;transform:rotate(135deg);}}& > div:first-of-type,& > div:last-of-type{border-bottom:2px solid var(--navy);}& > div:last-of-type{display:none;}}#moa-video{border-bottom:1.1111rem solid var(--navy);border-top-left-radius:0;border-top-right-radius:0;border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;padding-bottom:2.2222rem;padding-top:2.2222rem;img{margin-top:1.6667rem;}}#mobile-curve{transition:none !important;@media screen and (min-width:768px){display:none;}@media screen and (max-width:767px){background-color:transparent;background-image:url(/themes/custom/fluffiness/images/mobile-curve.svg);background-repeat:no-repeat;background-size:870px;background-position:calc(100% + 113px) 0;height:75px;position:absolute;right:0;top:20px;width:100%;z-index:1;&::before{content:"";background-color:var(--white);height:101px;margin-top:-100px;position:absolute;top:0;width:100%;}}}#ot-sdk-btn-floating.ot-floating-button button{align-items:center;display:flex !important;justify-content:center;}#overall-survival > .wrapper,#progression-free > .wrapper{@media screen and (max-width:767px){margin-bottom:0.85rem;overflow-x:scroll;width:100%;}img.mobile{@media screen and (max-width:767px){max-width:unset;position:relative;width:38.8889rem;}}}#overall-survival{@media screen and (max-width:767px){border-bottom-width:0.5556rem;&::after{display:none;}}&::after{height:295%;}}#page-navigation{height:9.4444rem;margin-bottom:-4.8889rem;@media screen and (max-width:1279px){margin-top:-1.1111rem;}}#phases{padding-bottom:2.2222rem;@media screen and (max-width:767px){padding-bottom:1.1111rem;}& > p{color:var(--dark-coral);margin-bottom:0.5556rem;&.coral{@media screen and (max-width:768px){padding-top:20px;}}}& > .list-wrapper{@media screen and (max-width:767px){flex-direction:column;}}.chart-wrapper{display:flex;height:16.6667rem;justify-content:space-between;margin-bottom:2.2222rem;margin-top:1.6667rem;@media screen and (max-width:767px){flex-direction:column;justify-content:flex-start;height:100%;margin-bottom:20px;}@media screen and (min-width:768px) and (max-width:1023px){height:20.8333rem;}@media screen and (min-width:1024px){height:18.3333rem;}> div{@media screen and (max-width:767px){width:100% !important;}}> div:first-of-type{align-items:center;display:flex;width:25%;@media screen and (max-width:767px){padding-bottom:5.5556rem;}.callout p:first-of-type{margin-bottom:0.5556rem;}}> div:nth-of-type(2){display:flex;flex-direction:column;justify-content:space-around;width:37.5%;@media screen and (max-width:767px){display:block;position:relative;margin-left:-10px;}> *{text-align:center;}> p{@media screen and (max-width:767px){font-size:18px;left:0;margin-left:2.2222rem;margin-top:-4.4444rem;position:absolute;top:0;width:120px !important;}@media screen and (max-width:400px){margin-top:-4.7222rem;width:4.7222rem;}}.callout{margin-left:1.8889rem;margin-right:1.8889rem;padding:0.4444rem;@media screen and (max-width:767px){border:0;bottom:0;margin-right:0;position:absolute;right:0;width:50%;p{font-size:18px;}}}.days{border-top:5px solid var(--navy);display:flex;justify-content:flex-start;position:relative;width:94%;&::after{content:"";background-image:url(/sites/default/images/graphic-arrowhead.png);background-repeat:no-repeat;background-size:contain;margin-right:-15px;margin-top:-19.5px;padding:0.8889rem;position:absolute;right:0;top:0;}@media screen and (max-width:767px){align-items:flex-start;border-left:0.1667rem solid var(--navy);border-bottom:0;border-right:0;border-top:0;border-width:7px;flex-direction:column;height:265px;margin-left:1.3889rem;margin-top:-6.1111rem;width:0.0556rem;&:before{content:"";display:block;position:absolute;top:82px;right:-140px;width:50px;height:105px;background:url(/themes/custom/fluffiness/images/chart-bracket.svg);background-repeat:no-repeat;}&::after{background-size:62%;bottom:0;height:1.1111rem;margin-right:-1.5556rem;margin-top:235px;position:absolute;right:0;transform-origin:0;transform:rotate(91deg);width:1.1111rem;}}p:first-of-type{margin-right:3.8889rem;}.day{margin-left:0.8333rem;position:relative;&::before{content:"";border:0.1667rem solid var(--navy);background-color:var(--mint);border-radius:1.1111rem;height:2.2222rem;width:1.3889rem;left:0;margin-top:-1.3889rem;position:absolute;top:0;}@media screen and (max-width:767px){p{font-size:18px;}&::before{margin-left:0 !important;transform:rotate(90deg) translate(17px,45px);}margin-left:30px;margin-top:75px;}&:first-of-type::before{margin-left:0.5556rem;}&:last-of-type::before{margin-left:0.8333rem;}& > p{margin-top:1.3889rem;@media screen and (max-width:767px){margin-top:0;text-align:left;width:100px;}@media screen and (max-width:359px){margin-left:-20px;}}}}.tradename{margin-left:1.1111rem;margin-right:1.1111rem;margin-top:-0.5556rem;padding:0.7778rem 0.2778rem;position:relative;@media screen and (max-width:767px){display:block;margin-left:0;margin-right:0;margin-top:-80px;position:absolute;right:-10px;top:0;width:53%;padding:0;p{font-size:16px;}&::before{content:none !important;}}@media screen and (min-width:768px) and (max-width:790px){margin-top:0;}&::before{content:"";border-bottom-left-radius:0.1667rem;border-bottom-right-radius:0.1667rem;border-left:0.2778rem solid var(--navy);border-right:0.2778rem solid var(--navy);border-top-left-radius:0.4444rem;border-top-right-radius:0.4444rem;border-top:0.2778rem solid var(--navy);height:2rem;left:0;position:absolute;top:0;width:100%;}p{padding:0 0.2778rem;margin-top:0.2222rem;}}}> div:last-of-type{color:var(--dark-mint);text-align:left;width:37.5%;@media screen and (max-width:767px){padding-top:1.1111rem;}.list-wrapper{margin-top:0.5556rem;&:first-of-type{margin-bottom:2.2222rem;@media screen and (max-width:767px){margin-bottom:0.5556rem;}}& > div:first-of-type{padding-right:0.5556rem;}}}.callout.mint{align-items:flex-start;color:var(--navy);display:flex;flex-direction:column;height:100%;padding:1.6667rem;@media screen and (max-width:767px){border-radius:1.6667rem !important;padding:1.1111rem;}@media screen and (min-width:768px) and (max-width:890px){padding-left:0.5556rem;}p:nth-of-type(2){text-align:left;}}.callout.navy{align-items:center;border-radius:1.11111rem;display:flex;flex-direction:column;height:100%;justify-content:space-evenly;@media screen and (max-width:767px){border-radius:1.66667rem !important;width:100%;}span{font-size:0.8rem;}}}.wrapper{margin-bottom:1.6667rem;& > p:first-of-type{color:var(--dark-coral);margin-bottom:0.5556rem;}}}#phase-2b{color:var(--body-color);@media screen and (max-width:767px){border-bottom-left-radius:0;border-bottom-right-radius:0;padding-bottom:1.1111rem;}}#preparation{border-top-left-radius:0;border-top-right-radius:0;@media screen and (max-width:767px){border-bottom-left-radius:0;border-bottom-right-radius:0;}h2{margin-bottom:1.1111rem;}h3{margin-bottom:1.1111rem;}}#recommended-dosage{&::after{margin-top:-1.9444rem;}&::before{margin-top:-14.7222rem;}@media screen and (max-width:767px){border-bottom-left-radius:0;border-bottom-right-radius:0;padding-bottom:1.6667rem;&::after{margin-top:-15rem;}&::before{display:none;}}& > p{color:var(--body-color);}h2{margin-bottom:0.5556rem;margin-top:-0.5556rem;}h3{color:var(--dark-mint);margin-bottom:1.1111rem;margin-top:0.5556rem;}h4{margin-bottom:1.1111rem;margin-top:1.1111rem;}.definition{margin-top:1.1111rem;}.list{margin-bottom:1.1111rem;@media screen and (max-width:767px){margin-bottom:0;}}.wrapper{align-items:center;border-radius:1.1111rem;border:0.5556rem solid var(--navy);display:flex;flex-direction:column;margin-bottom:1.1111rem;overflow:hidden;text-align:center;@media screen and (max-width:767px){border:0.1667rem solid var(--navy);}.items{align-items:stretch;display:flex;width:100%;@media screen and (max-width:767px){flex-direction:column;}& > div{align-items:center;display:flex;flex-direction:column;padding:1.1111rem 2rem 0.8333rem 2rem;width:calc(100% / 3);@media screen and (max-width:767px){padding:1.6667rem 2rem 1.1111rem 2rem;width:100%;}img{margin-bottom:1.1111rem;max-width:6.6667rem;}}& > div:nth-of-type(2){border-left:0.0556rem solid var(--light-navy);border-right:0.0556rem solid var(--light-navy);@media screen and (max-width:767px){border-bottom:0.1111rem solid var(--navy);border-left:0;border-right:0;border-top:0.1111rem solid var(--navy);}}}.title{background-color:var(--coral);color:var(--white);padding-bottom:0.2778rem;padding-top:0.2778rem;width:100%;@media screen and (max-width:767px){padding:0.5556rem 0;}}}}#responses-in-patients{.definition{color:var(--body-color);}.grid .wrapper{border-radius:1.1111rem;display:flex;margin-top:1.3889rem;margin-bottom:1.6667rem;overflow:hidden;& > div{width:50%;text-align:center;&:first-of-type{border-bottom-left-radius:1.1111rem;border-top-left-radius:1.1111rem;& > div{margin-right:0.5556rem;padding-right:0;}}&:last-of-type{border-bottom-right-radius:1.1111rem;border-top-right-radius:1.1111rem;& > div{margin-left:0.5556rem;padding-left:0;}}& > div:first-of-type{background-color:var(--navy);color:var(--white);& > p:nth-of-type(2){color:var(--mint);}}& > div{padding:1.6667rem;}& > div:last-of-type{color:var(--navy);background-color:var(--mint);& > p:nth-of-type(2){color:var(--dark-coral);sup{top:-0.7222rem;}}}& > div p:nth-of-type(2){font-size:2.7778rem;margin:0.5556rem 0;}}}}#responses-sustained{.blue-corner-box{background-color:var(--navy);bottom:0;height:13px;margin-bottom:-19px;position:absolute;right:-10px;width:30px;@media screen and (max-width:768px){display:none;}}.definition{color:var(--body-color);}.wrapper{align-items:flex-start;display:flex;justify-content:space-between;margin-bottom:1.3889rem;margin-top:1.3889rem;@media screen and (max-width:767px){flex-direction:column;margin-bottom:-0.5556rem;margin-top:0.2778rem;}& > img{width:100%;@media screen and (max-width:767px){width:100%;}}& > .callout{width:25%;@media screen and (max-width:767px){margin-bottom:-0.6667rem;margin-top:0.8333rem;width:100%;}}}}#resources{border-bottom:1.1111rem solid var(--navy);&::after{margin-top:-1.9444rem;}&::before{margin-top:-14.7222rem;margin-right:-13.5556rem;}@media screen and (min-width:768px){border-bottom-left-radius:2.2222rem;border-bottom-right-radius:2.2222rem;}@media screen and (max-width:767px){&::after{height:130%;margin-bottom:1.1111rem;}border-bottom-width:0.5556rem;}& > p{margin-bottom:1.6667rem;}.blue-corner-box{background-color:var(--navy);bottom:0;height:0.5556rem;margin-bottom:-1.0833rem;margin-right:-1.2222rem;position:absolute;right:0;width:2.7778rem;@media screen and (max-width:767px){display:none;}}.items{display:flex;justify-content:space-between;margin-top:1.3889rem;@media screen and (max-width:767px){flex-direction:column;}& > div{width:49%;@media screen and (max-width:767px){width:100%;}}.item{align-items:center;border:2px solid var(--navy);display:flex;flex-direction:column;height:27.2222rem;justify-content:space-between;margin:0 0.2778rem;@media screen and (max-width:767px){height:29rem;margin:0 auto 0.5556rem;border-radius:0 !important;}&:first-of-type{border-top-left-radius:1.1111rem;border-bottom-left-radius:1.1111rem;margin-left:0;@media screen and (max-width:767px){border-top-left-radius:15px !important;border-top-right-radius:15px !important;border-bottom-left-radius:0 !important;border-bottom-right-radius:0 !important;}}&:last-of-type{border-top-right-radius:1.1111rem;border-bottom-right-radius:1.1111rem;margin-right:0;@media screen and (max-width:767px){border-top-left-radius:0 !important;border-top-right-radius:0 !important;border-bottom-left-radius:15px !important;border-bottom-right-radius:15px !important;}}&:nth-of-type(2) .title p:last-of-type{@media screen and (max-width:767px){margin-top:1.1111rem;}}&.fpo{height:23rem;}&.invisible{@media screen and (max-width:767px){display:none;}}&.bottom-no-radius{@media screen and (max-width:767px){border-bottom-right-radius:0 !important;border-bottom-left-radius:0 !important;}}&.border-all-rounded{@media screen and (max-width:767px){border-radius:15px !important;}}& > p{position:relative;top:-1.6667rem;}.button{background-position-y:center;background-repeat:no-repeat;padding-right:3.0556rem;}.button.download{background-image:url("/sites/default/images/icon-download.svg");background-position-x:7.7778rem;display:block;@media screen and (max-width:767px){background-position-x:8.3333rem;}&:focus,&:hover,&:focus-visible{box-shadow:var(--box-shadow-1);outline:0;transform:scale(1.05);}}.button.play{background-image:url("/sites/default/images/icon-play.svg");background-position-x:5.0556rem;}}.item .title{align-items:center;display:flex;flex-direction:column;width:100%;img{border:1px solid var(--body-color);margin-bottom:1.3333rem;margin-top:1.6667rem;max-width:7.2222rem;}p{color:var(--navy);font-size:1.3333rem;font-weight:bold;padding:0 0.2778rem;text-align:center;text-transform:uppercase;&:nth-of-type(2){color:var(--dark-mint);font-family:"Nolan";margin-bottom:1.3889rem;padding-left:1.1111rem;padding-right:1.1111rem;@media screen and (max-width:767px){margin-bottom:0;}&.single-line{line-height:50px;@media screen and (max-width:767px){line-height:normal;}}}&:last-of-type{color:var(--body-color);font-size:1rem;font-weight:normal;max-width:16.6667rem;text-transform:initial;@media screen and (max-width:767px){margin-top:1.1111rem;}}}.fpo{border:0.1667rem solid var(--fpo);color:var(--fpo);font-size:2.7778rem;margin-bottom:1.6667rem;margin-top:1.1111rem;max-width:14.7222rem;padding:0.8333rem 0;width:90%;}}+ .items{@media (max-width:768px){margin-top:0;.item:first-of-type{border-top-right-radius:0 !important;border-top-left-radius:0 !important;}}}}.wrapper{margin-top:1.9444rem;}.wrapper:nth-of-type(3){& > .items:first-of-type > .item:last-of-type{@media screen and (max-width:767px){border-radius:0;}}}.wrapper:nth-of-type(4) .items > .item:first-of-type{border-radius:1.1111rem;}}#progression-free > p,#responses-in-patients > p,#responses-sustained > p{margin-bottom:0.5556rem;}#progression-free > p,#overall-survival > p{&.mint{color:var(--dark-mint);}&.mobile-only{display:none;@media screen and (max-width:767px){display:block;}}}.bg-coral{background-color:var(--coral) !important;}.bg-green{background-color:var(--dark-mint) !important;}.bg-mint{background-color:var(--mint) !important;}.bg-navy{background-color:var(--navy) !important;}.blue-box{border-top-left-radius:2.2222rem;border-top-right-radius:2.2222rem;border-left:1.1111rem solid var(--navy);border-right:1.1111rem solid var(--navy);border-top:1.1111rem solid var(--navy);color:var(--body-color);margin:0 auto;max-width:66.6667rem;padding-bottom:2.2222rem;padding-left:5.1111rem;padding-right:5.1111rem;padding-top:1.6667rem;position:relative;&:first-of-type::after,&:last-of-type::after{content:"";border-right:55px solid var(--navy);height:100%;position:absolute;right:0;}&:first-of-type::after{margin-right:-3.2778rem;bottom:0;}&:first-of-type::before{content:"";background-image:url(/sites/default/images/graphic-curves-desktop.png?v=1);background-repeat:no-repeat;background-size:cover;height:26.3333rem;margin-right:-13.5556rem;margin-top:-17.3889rem;position:absolute;right:0;top:0;width:25.3889rem;transition:none !important;}@media screen and (max-width:767px){&:first-of-type::before{background-color:var(--white);background-size:100%;height:2.5556rem;margin-right:-2.0833rem !important;margin-top:-27.4444rem;width:3.7222rem;}}&:last-of-type{&::after{content:"";border-bottom-right-radius:2.2222rem;bottom:0;margin-bottom:-1.0556rem;margin-right:-3.2778rem;}&::before{content:"";bottom:0;margin-bottom:-1.0556rem;margin-right:-0.1667rem;padding:0.5556rem;position:absolute;right:0;}@media screen and (max-width:767px){&::before{display:none;}}}@media screen and (max-width:767px){border-left-width:0.5556rem;border-radius:0.8333rem;border-right-width:0.5556rem;border-top-width:0.5556rem;padding-bottom:1.1111rem;padding-left:0.5556rem;padding-right:0.5556rem;padding-top:1.1111rem;&:first-of-type,&:last-of-type{border-radius:0.8333rem;}&:first-of-type::after{border-right-width:0.5278rem;margin-bottom:0;margin-right:0;margin-top:-4.5556rem;right:-0.5556rem;height:200%;}&:last-of-type{border-bottom-width:0.5rem;}}@media screen and (min-width:768px) and (max-width:1239px){padding-left:1.6667rem;padding-right:1.6667rem;max-width:90%;}& > p{margin-bottom:0.5556rem;}h2{font-size:1.5556rem;font-weight:bold;text-transform:uppercase;}h4{color:var(--dark-mint);font-size:1.3333rem;font-weight:normal;margin-bottom:1.6667rem;text-transform:uppercase;}}.border-bottom-0{border-bottom:0 !important;}.border-bottom-left-0{border-bottom-left-radius:0 !important;}.border-bottom-right-0{border-bottom-right-radius:0 !important;}.border-all-rounded{border-radius:1.111rem !important;}.border-right-1{border-right:0.0556rem solid var(--white) !important;}.border-left-1-gray{border-left:0.0556rem solid var(--gray) !important;}.border-right-0{border-right:0 !important;}.border-right-1-gray{border-right:0.0556rem solid var(--gray) !important;}.border-top-0{border-top:0 !important;}.border-top-left-0{border-top-left-radius:0 !important;}.border-top-right-0{border-top-right-radius:0 !important;}.border-top-light-navy-1{border-top:1px solid var(--light-navy) !important;}.mb-0{margin-bottom:0 !important;}.m-mb-5{@media screen and (max-width:767px){margin-bottom:0.2778rem;}}.button{align-items:center;background-color:var(--dark-mint);border-radius:2.2222rem;color:var(--white);font-weight:bold;letter-spacing:normal;padding:1rem 1.3889rem;text-decoration:none;text-transform:uppercase;&:focus,&:focus-visible,&:hover{transform:scale(1.05);}}.callout{color:var(--white);border-radius:1.1111rem;font-size:1.1111rem;font-weight:bold;padding:1.1111rem;text-align:center;@media screen and (max-width:767px){border-radius:0.8333rem !important;}&.navy{background-color:var(--navy);border-radius:0.5556rem;}&.coral{background-color:var(--coral);}&.green{background-color:var(--dark-mint);}&.mint{background-color:var(--mint);}&.red{background-image:var(--linear-gradient-red);}}.container{margin:0 auto;max-width:54.4444rem;width:100%;@media screen and (max-width:767px){padding-left:1.6667rem;padding-right:1.6667rem;}@media screen and (min-width:768px) and (max-width:1023px){max-width:41.5556rem;}@media screen and (min-width:1024px) and (max-width:1279px){max-width:54.6667rem;}@media screen and (min-width:1280px){max-width:54.4444rem;}}.definition,.definition > *,.disclaimer,.disclaimer > *{font-size:0.8889rem;position:relative;}.definition.border-bottom-navy-1{border-bottom:2px solid var(--navy);margin-bottom:0;padding-bottom:1.3333rem;}.definition p{margin-bottom:10px;}.desktop{@media screen and (max-width:767px){display:none;}}.desktop-br{@media screen and (min-width:767px){display:block;height:0;}}.dialog-off-canvas-main-canvas{overflow:hidden;}.font-gantari{font-family:"Gantari" !important;}.font-nolan{font-family:"Nolan" !important;}#signup-form{input[type="checkbox"]{display:none;}#consent p:nth-child(1){padding-left:0;}input[type="checkbox"]:checked + label::before,#consent input[type="checkbox"]:checked ~ .form-field::before{background-image:url('data:image/svg+xml,%3Csvg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" fill="black"%3E%3Cpath d="M13.854 4.854a.5.5 0 0 0-.708-.708L6.5 11.293 3.854 8.646a.5.5 0 1 0-.708.708l3 3a.5.5 0 0 0 .708 0l7-7z"/%3E%3C/svg%3E');}#consent p.checked::before{background-image:url('data:image/svg+xml,%3Csvg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" fill="black"%3E%3Cpath d="M13.854 4.854a.5.5 0 0 0-.708-.708L6.5 11.293 3.854 8.646a.5.5 0 1 0-.708.708l3 3a.5.5 0 0 0 .708 0l7-7z"/%3E%3C/svg%3E');}.scroll-container{height:71vh;max-height:785px !important;}.checkbox-wrap label,#consent p{position:relative;align-items:center;cursor:pointer;padding-left:20px;font-size:16px;-webkit-user-select:none;-moz-user-select:none;user-select:none;}.checkbox-wrap label::before,#consent p:nth-child(1)::before{content:"";position:absolute;left:0;width:15px;height:15px;border:1px solid var(--body-color);transition:all 0.3s ease;}.checkbox-wrap.error label::before,#consent p.error::before{border-color:red;}.checkbox-wrap.error label::before,#consent p.error::before{border-color:red;background-color:#ffebeb;}button.valid{background-color:var(--dark-mint);color:var(--white);}button[disabled]{cursor:not-allowed;}}.form-field{&.consent > span:not(.error-msg){clear:both;display:block;}&.error{input{border-color:var(--error) !important;border-width:2px !important;}.error-msg{visibility:visible;}}.error-msg{color:var(--error);font-size:0.7778rem;margin-top:0.2778rem;display:none;}}.mobile{@media screen and (min-width:768px){display:none;}}.hang{font-size:75%;line-height:0;margin:0.3889rem -0.3889rem;position:absolute;&.over{margin-left:-0.6667rem;}&.tight{margin-left:-0.1667rem;}&.small{top:-0.15rem;}&.asterisk{font-size:100%;margin-top:10px;}}.invisible{visibility:hidden;}.layout-container{&::before{background-image:url(/sites/default/images/graphic-curve-bg.png);background-position:-63.3333rem 7.2222rem;background-repeat:no-repeat;background-size:350% 350%;height:100%;position:fixed;right:0;top:0;width:100%;z-index:13;}}.list-wrapper{display:flex;}.mb-10{margin-bottom:1.1111rem !important;}.mb-15{margin-bottom:1.6667rem !important;}.mt-15{margin-top:1.6667rem !important;}.next-page-button,.prev-page-button{background-color:var(--navy);border-radius:0.5556rem;color:var(--white);cursor:pointer;font-family:"Nolan";font-weight:bold;padding-bottom:0.8333rem;padding-left:1.6667rem;padding-right:1.6667rem;padding-top:0.8333rem;position:relative;text-transform:uppercase;width:10.8333rem;z-index:1;&:hover{background-color:var(--dark-mint);transform:scale(1.05);}@media screen and (max-width:1279px){font-size:1.1111rem;}span{font-weight:lighter;letter-spacing:0.0556rem;}}.next-page-button{display:flex;flex-direction:column;height:100%;justify-content:center;margin-right:-8.3333rem;max-width:13.6111rem;padding-right:3.3333rem;right:0;top:-0.5556rem;width:100%;&::after{content:"";border-right:0.1667rem solid var(--mint);border-top:0.1667rem solid var(--mint);margin-right:1.5rem;padding:0.3889rem;position:absolute;right:0;top:50%;transform:translateY(-50%) rotate(45deg);}@media screen and (max-width:1279px){height:4.4444rem;margin-right:0;margin-top:-4.4444rem;position:absolute;top:0;width:8.3333rem;}&:hover{&::after{border-right-color:var(--white);border-top-color:var(--white);}}& > div{@media screen and (max-width:1279px){margin-top:0;}}}.nowrap{white-space:nowrap;}.prev-page-button{display:flex;flex-direction:column;left:0;margin-left:-6.1111rem;padding-left:3.8889rem;position:absolute;&::after{content:"";border-right:0.1667rem solid var(--mint);border-top:0.1667rem solid var(--mint);margin-left:1.5rem;margin-top:1.8889rem;padding:0.3889rem;position:absolute;left:0;top:0;transform:rotate(230deg);}@media screen and (max-width:1279px){margin-left:0;margin-top:0;}&:hover{&::after{border-right-color:var(--white);border-top-color:var(--white);}}}.region-header{color:var(--navy);.site-name{display:none !important;}}.region-hero{position:relative;&::after,&::before{content:"";margin-top:0.1111rem;max-width:100%;position:absolute;top:0;}&::after{border-top:3.2778rem solid var(--mint);left:0;width:100%;z-index:10;}&::before{background-color:var(--coral);height:3.3333rem;margin-top:0.0556rem;right:0;width:12%;z-index:11;}@media screen and (max-width:767px){&::after{display:none;}&::before{display:none;}}& > div{align-content:flex-start;display:flex;margin:0 auto;max-width:68rem;padding-bottom:0;padding-top:5.5556rem;position:relative;z-index:13;@media screen and (max-width:767px){flex-direction:column;padding-top:2.2222rem;}}h2{font-size:2.2222rem;font-weight:bold;max-width:90%;text-transform:uppercase;@media screen and (max-width:767px){font-size:1.7778rem;margin-left:1.6667rem;padding-right:1.6667rem;}}img{margin-left:1.389rem;margin-right:1.2222rem;margin-top:0.5556rem;max-width:4.5rem;width:auto;@media screen and (max-width:767px){margin-bottom:0.8333rem;}}}.region-isi{color:var(--body-color);margin-bottom:2.2222rem;@media screen and (max-width:767px){margin-bottom:0;}p{margin-bottom:1.1111rem;}.indication > p:last-of-type{margin-bottom:0 !important;}}.region-modals{margin-top:4.4444rem;}.region-page-navigation{.container{display:flex;justify-content:flex-end;margin-bottom:1.1111rem;margin-top:2.7778rem;position:relative;}.next-page-button,.prev-page-button{@media screen and (max-width:1023px){margin-top:0;max-width:100%;}@media screen and (min-width:1024px){margin-top:0;}}}.region-references{color:var(--body-color);display:flex;flex-direction:row-reverse;justify-content:flex-end;margin-bottom:1.6667rem;margin-top:0;position:relative;strong{color:var(--navy);font-weight:bold;}& > div:last-child{padding-right:2.2222rem;@media screen and (max-width:1279px){margin-top:0.2778rem;padding-right:0;}p{@media screen and (max-width:1279px){font-size:1rem;}}}}.site-logo{max-width:10.6667rem;}.table{border:0.5556rem solid var(--navy);border-radius:1.1111rem;margin-bottom:1.6667rem;margin-top:1.6667rem;overflow:hidden;width:100%;@media screen and (max-width:767px){border:0.1667rem solid var(--navy);border-radius:0.8333rem;}table{background-color:var(--navy);width:inherit;thead{overflow:hidden;position:relative;}tbody{position:relative;top:-0.0556rem;}}tbody tr{border-bottom:0.0556rem solid var(--gray);border-right:0;&.no-border,&.title{border-bottom:0.1111rem solid var(--white);}}td{color:var(--navy);line-height:normal;padding:0.1111rem 0.8333rem;width:auto;}td:last-of-type{text-align:left;}tr:not(.title) td{background-color:var(--white);border-right:0.0556rem solid var(--gray);line-height:normal;text-align:left;@media screen and (max-width:767px){padding-bottom:0.5556rem;padding-left:0.8333rem;padding-top:0.5556rem;}&:last-of-type{border-right:0;text-align:center;}}.border-right-white{border-right:0.0556rem solid var(--white) !important;}.lt-green-bg{background-color:var(--light-mint);th{background-color:var(--light-mint);color:var(--navy);}}.red-header{td{border-bottom:0;}th{background-color:var(--coral);color:var(--white);padding-top:0.35rem;padding-bottom:0.35rem;@media screen and (max-width:767px){padding-bottom:0.5556rem;padding-top:0.5556rem;}}}.title{background-color:var(--mint);color:var(--navy);.section-header{text-align:left;@media screen and (max-width:767px){line-height:1.1111rem;padding-bottom:0.5556rem;padding-left:0.8333rem;padding-top:0.5556rem;}}}}.text-body{color:var(--body-color);}.text-align-center{text-align:center !important;}.text-align-left{text-align:left !important;}.text-coral{color:var(--coral);}.text-dark-mint{color:var(--dark-mint) !important;}.text-block-center{display:inline-block;text-align:center;width:100%;}.text-navy{color:var(--navy) !important;}.text-magenta{color:magenta;}.text-white{color:var(--white) !important;}.text-transform-initial{text-transform:initial !important;}.text-transform-uppercase{text-transform:uppercase !important;}.transcript-box{&.plus{button::before{background-image:url("/sites/default/images/icon-transcript-plus.png");}.transcript-copy-box{height:0;}}&.minus{button::before{background-image:url("/sites/default/images/icon-transcript-minus.png");}.transcript-copy-box{transition:height 0.5s linear;height:auto;}}button{padding-left:1.6667rem;position:relative;margin-top:1.1111rem;&::before{content:"";background-size:cover;left:0;padding:0.6667rem;position:absolute;top:0;}}p{margin-bottom:1.1111rem;}.transcript-copy-box{height:0;margin-bottom:1.6667rem;overflow:hidden;position:relative;}}.view-homepage-ctas{margin:0 auto;max-width:var(--container-max-width);}#block-fluffiness-definitionblockaccessandsupport{p{color:var(--body-color);}}.tracking-5{letter-spacing:3px;}.margin-top-10{margin-top:10px !important;}.margin-top-20{margin-top:20px !important;}.margin-bottom-10{margin-bottom:10px !important;}.margin-bottom-20{margin-bottom:20px !important;}.smaller-font{font-size:0.88em;}#toolbar-administration{position:fixed;z-index:1000;}.toolbar-fixed header[role="banner"]{top:39px;}.toolbar-fixed.toolbar-tray-open header[role="banner"]{top:79px;}body.toolbar-fixed{padding-top:117px !important;}